This study aims to explore the application of the NSR(Net Smelter Return) method in open-pit optimizing of polymetallic orebodies to improve resource utilization efficiency and economic benefits. Given the characteristics of polymetallic orebodies, such as complex orebody morphology and significant grade variations, this research establishes a geoogical model based on the NSR method and optimize the open-pit mining boundaries. Research shows that: (1) The NSR method optimizes open-pit by calculating the net revenue of ore blocks, taking into account the geological characteristics and economic factors of the ore comprehensively, making the boundary delineation more scientific and reasonable. (2) NSR can be used to determine the mining priority of different ore bodies, providing a basis for investment decisions. This helps mine to make scientific decisions in a complex market environment, thereby improving overall economic efficiency. (3) Compared to the equivalent grade pit optimization method, the NSR boundary optimization method extracts less ore, with higher grade and greater revenue, thereby optimizing resource utilization and reducing the mining of low-grade ore. This is particularly suitable for dealing with complex ore bodies or low-grade ore deposits and can significantly improve resource utilization. Additionally, the NSR method exhibits good adaptability and flexibility in optimizing open-pit boundaries for polymetallic orebodies, providing a new approach for open-pit mine optimization planning. This study has important theoretical and practical implications, offering valuable insights for the optimization of open-pit mining in polymetallic orebodies.