Abstract:A gold mine in Guizhou contains arsenic, sulfur and carbon. Its a fine-grained disseminated gold deposit and a typical Carlin-type refractory gold deposit. A series of flotation parameters such as grinding fineness, pH regulator, copper sulfate dosage and collector type were tested, and no good flotation effect was obtained. The concentrate rate was low, the gold grade enrichment degree was low, the gold recovery rate was less than 60%, and the gold loss of tailings was high. In view of the above problems, this paper broke through the limitations of traditional flotation process, and innovatively proposed a treatment technology of pressurized oxidation-cyanidation of refractory gold ore and easy flotation gold concentrate. This method comprehensively considers the acid-base balance, thermodynamic balance and efficient utilization of resources in ore treatment. The ore blending of refractory gold ore and easy-to-float gold concentrate can not only comprehensively utilize the excess acid generated by the oxidation of refractory gold ore, but also achieve a gold leaching rate of 98%, which greatly improves the economic value and development and utilization efficiency of refractory mineral resources.